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Technical Program
Paper Detail
| Paper: | MA-P4.2 |
| Session: | Image Registration/Alignment and Mosaicking |
| Time: | Monday, October 9, 09:40 - 12:20 |
| Presentation: |
Poster
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| Title: |
IMAGE REGISTRATION OF DIFFERENTLY STAINED HISTOLOGICAL SECTIONS |
| Authors: |
Jens-Peer Kuska; University Leipzig | | | | | Ulf-Dietrich Braumann; University Leipzig | | | | | Nico Scherf; University Leipzig | | | | | Markus Löffler; University Leipzig | | | | | Jens Einenkel; University Leipzig | | | | | Michael Höckel; University Leipzig | | | | | Lars-Christian Horn; University Leipzig | | | | | Nicolas Wentzensen; University Heidelberg | | | | | Magnus von Knebel Doeberitz; University Heidelberg | | |
| Abstract: |
We have focused our interest on the registration of brightfield transmitted light microscopy images with respect to different histological stainings. For this kind of registration problem we have developed a new segmentation procedure. Based on the obtained consistent segmentations, a nonlinear registration transformation is computed. The applied registration procedure uses a curvature-based nonlinear partial differential equation in order to find the appropriate mapping between the images. We present an example for the registration of images of two consecutive histological sections from a uterine cervix specimen, where one section stained with p16^INK4a was mapped onto another with H&E staining. Finally, we give an illustrative example for a tissue volume reconstruction based on an alternately stained large serial section. |
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